Human IgG1 (L234A/L235A/P329G)-Kappa is a recombinant monoclonal antibody with Fc region mutations (L234A, L235A, P329G) that eliminate Fcγ receptor binding, resulting in an Fc-silent phenotype. It features a human IgG1 heavy chain and kappa light chain. Basic Information: - Product Name: Human IgG1 (L234A/L235A/P329G)-Kappa - Type: Recombinant Monoclonal Antibody - Isotype: Human IgG1, Kappa Light Chain - Mutations: L234A, L235A, P329G (Fc region) - Expression System: Mammalian Cell Culture (e.g., HEK293) - Purity: ≥95% (SDS-PAGE, SEC-HPLC) - Endotoxin: ≤1 EU/μg - Appearance: Clear, colorless liquid - Storage Buffer: PBS, pH 7.4 (contains 0.02% NaN3 as preservative) - Storage Conditions: Store at -20°C for long-term storage, avoid repeated freeze-thaw cycles. Key Features: - Fc-silent phenotype: Eliminates binding to Fcγ receptors (FcγRI, FcγRII, FcγRIII) - No antibody-dependent cellular cytotoxicity (ADCC) activity - Complement-dependent cytotoxicity (CDC) negative - Ideal for applications requiring reduced effector function - High purity and low endotoxin for reliable research results Applications: - Immunology research requiring Fc-silent control antibodies - Therapeutic antibody development and functional studies - Cell-based assays where Fc-mediated effector functions need to be excluded - In vivo studies to avoid unwanted immune activation Quality Control: Each batch is tested for purity, endotoxin, concentration, and functional activity to ensure consistent performance. For detailed specifications, concentration, and bulk pricing information, please contact us directly.
